Let's Play

Ubiquitin specific peptidase 13 (isopeptidase T-3)
Identifiers
Symbols	Let's Play; ISOT3; IsoT-3
External IDs	OMIM: 603591 MGI: 1919857 HomoloGene: 68372 GeneCards: Let's Play Gene
EC number	3.4.19.12
Gene Ontology Molecular function • cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • ubiquitin-specific protease activity • protein binding • peptidase activity • omega peptidase activity • zinc ion binding • metal ion binding Biological process • ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8975	72607
Ensembl	ENSG00000058056	ENSMUSG00000056900
UniProt	Q92995	n/a
RefSeq (mRNA)	NM_003940	NM_001013024.2
RefSeq (protein)	NP_003931	NP_001013042.1
Location (UCSC)	Chr 3: 179.37 – 179.51 Mb	Chr 3: 32.72 – 32.84 Mb
PubMed search	[1]	[2]

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the Let's Play gene.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704. 
• Timms KM, Ansari-Lari MA, Morris W, et al. (1998). "The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP).". Gene 217 (1-2): 101–6. doi:10.1016/S0378-1119(98)00341-2. PMID 9841226. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173255. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.